Estrange is one of three winners out of the unraced Alienate (Oasis Dream), who is also the dam of Lmay (Frankel), third in the Gr.2 Park Hill Stakes, and of Basalt (Pinatubo), stakes-placed in England and Qatar. Alienate is a half-sister to four stakes winners, headed by the sire Logician (Frankel), winner of the Gr.1 St Leger. The others are Suffused (Champs Elysees), a triple graded winner in the US and second in the Grade 1 E. P. Taylor Stakes, who is the dam of Sunly (Night Of Thunder), winner of the Gr.3 Prix de Royaumont and the Gr.3 Prix Allez France, Okeechobee (Time Test), winner of the Gr.3 Gordon Richards S., and Collide (Frankel), a Listed winner in France.

Second dam Scuffle (Daylami) won three races, was Listed-placed and bred eight winners. She is also the dam of Alienate's full-sister Sleep Walk, who produced Whitebeam (Caravaggio), twice winner of the Grade 1 Diana Stakes.

Third dam Tantina (Distant View) won two Listed races in Britain and had four winners, among them the Group 1-winning sire Cityscape (Selkirk), successful at the top level in the UAE, and the sire Bated Breath (Dansili), winner of the Gr.2 Temple S. and multiple Group 1-placed.

Tantina is also the grandam of the Group 1 sprinter Equilateral (Equiano), who won the Gr.2 Meydan Sprint.

Alienate has a yearling filly by Blue Point and a filly foal who is a full-sister to Estrange.