Mangoustine is the fourth foal and first winner out of Zotilla (Zamindar), who ran once. Zotilla is a half-sister to Flotilla (Mizzen Mast), winner of the Gr.1 Poule d'Essai des Pouliches and the Grade 1 Breeders' Cup Juvenile Fillies Turf, and to the unraced Ourebi (Frankel).

Second dam Louvain (Sinndar) won the Grade 3 Miesque S. in the US. She is also the dam of Big Five (Frankel), winner of the Listed Prix Right Royal, and the stakes winner Louvakhova (Maria's Mon), who produced Crossfirehurricane (Kitten's Joy), winner of the Gr.3 Gallinule S., and My Generation (Speightstown), winner of the Listed Patton S. Louvain is a half-sister to Laajooj (Azamour), winner of the Listed Fairway S., and to Desert Poppy (Oasis Dream), placed in the Gr.3 Bengough S.

Third dam Flanders (Common Grounds), a Listed-winning sprinter who was second in the Gr.2 King's Stand S., produced G Force (Tamayuz), winner of the Gr.1 Haydock Sprint Cup. She is a half-sister to the dams of Lethal Force (Dark Angel), winner of the Gr.1 Diamond Jubilee S. and the Gr.1 July Cup and later a sire, and of the Group 2 winners Family One (Dubai Destination) and Juliet Capulet (Dark Angel).

Family One was also second in the Gr.1 Prix Morny, and Juliet Capulet won the Gr.2 Rockfel S.

Zotilla has a two-year-old colt by Zoustar and a filly foal by Too Darn Hot, and she is in foal to Dubawi.