Cyberknife is out of Awesome Flower (Flower Alley), a multiple stakes winner who was three times graded stakes-placed, including at Grade 2 level. He is a half-brother to the winner Zia's Song (Kitten's Joy). Awesome Flower is a half-sister to the Grade 3-placed First Mondays (Curlin), the stakes-placed If Not For Her (Not For Love) and the winner How My Heart Works (Not For Love), dam of Monday Morning QB, a stakes winner placed at Grade 3 level.

Second dam Formalities Aside (Awesome Again) won at two. She is a half-sister to Well Armed (Tiznow), winner of the Gr.1 Dubai World Cup and the Grade 1 Goodwood Stakes, to the Grade 3 winner Witty (Distorted Humor), dam of the Grade 3 winner Bombard and the Grade 2-placed Amuse, to Helsinki (Distorted Humor), third in the Grade 1 Travers Stakes, and to the stakes-placed Only In America (Tiznow).

Third dam Well Dressed (Notebook) was a stakes winner. Her daughter Life Well Lived (Tiznow) is the dam of the sire American Patriot, winner of the Grade 1 Maker's 46 Mile Stakes, and the unraced O' Toole (Distorted Humor) produced the stakes winner Lady O'Toole and the twice Grade 3-placed Sister Otoole and is the grandam of the sire Mr Money, a Grade 3 winner and second in the Grade 1 Pennsylvania Derby.

Awesome Flower has the unraced two-year-old colt Tapit Shoes (Tapit) and a weanling colt by Authentic, and she was bred back to Gun Runner in 2022.